Uma ungumthandi wezokwelapha ohlukile oneso elibukhali lamathrendi asafufusa nokukhishwa kwemikhiqizo emisha, kufanele ukuthi uqaphele ukwenyuka okukhulu kwesidingo se-pterostilbene.
I-Pterostilbene iyinhlanganisela yezitshalo eyenzeka ngokwemvelo futhi etholakala ezithasiselweni zokudla, ethandwa kakhulu ngezakhiwo zayo ezinkulu zokwelapha. Into ngokuyinhloko isebenza njenge-antioxidant, iphikisana nemiphumela eyingozi yama-radicals mahhala emzimbeni. Ucwaningo lubonisa ukuthi lungasiza ngochungechunge olubanzi lwezinye izinkinga zezokwelapha.
Uma uzibuza ukuthi ingabe i-pterostilbene iphila ngokuvumelana nezimangalo zayo zokwelapha, ufike endaweni efanele. Nakhu konke okumele ukwazi mayelana nalesi sithako sokwelapha esithathwe yisitshalo esisha.
Iyini i-Pterostilbene?
I-Pterostilbene, eyaziwa kakhulu ngokuthi i-trans-3,5-dimethoxy-4-hydroxystilbene, iyinhlanganisela yemvelo ezitshalweni eyaziwa kakhulu ngezakhiwo zayo zokulwa ne-antioxidant. Le nto idlala indima ebalulekile ye-phytoalexin ezitshalweni eziyikhiqizayo, isiza ekugwemeni izifo zokukhunta kanye namagciwane.
I-Pterostilbene ingeyeqembu lama-phenylpropanoid okuthiwa ama-stilbenoids. Zihlobene ngamakhemikhali ne-resveratrol edume kakhulu.
Njengamanye ama-stilbenoid amaningi, i-pterostilbene ayizuzi nje izitshalo. Inhlanganisela ingase futhi ibe nemiphumela yayo yokwelapha kubantu.
Izinzuzo ze-Pterostilbene zibangelwa kakhulu yi-antioxidant, anti-inflammatory, antimicrobial, antifungal, kanye ne-antibacterial properties. Izigaba ezilandelayo zizongena zijule ekusetshenzisweni kwemithi ye-stilbenoid.
Ihluke Kanjani I-Pterostilbene Ku-Resveratrol?
Kokubili i-pterostilbene ne-resveratrol kungokwesigaba se-stilbenoid se-phenylpropanoids. Kodwa-ke, ama-compounds ahluke kakhulu ku-bioavailability yawo.
I-Bioavailability iphesenti lenhlanganisela yokwelapha efika egazini uma kuqhathaniswa nesamba somthamo osetshenzisiwe. Kuyaziwa nangokuthi izinga lokumunca.
I-Pterostilbene ine-bioavailability efika ku-80% uma kuqhathaniswa nama-20% we-resveratrol.
Ithamo lomthamo, i-pterostilbene iphumelela kakhulu kune-resveratrol. Izinga layo eliphezulu lokumunca libangelwa amaqembu amabili e-methoxy asebenzayo esakhiweni sawo samangqamuzana.
Ungayitholaphi i-Pterostilbene?
Wonke ama-stilbenoid ngokuvamile akhiqizwa uhlobo olufanayo.
Abacwaningi besayensi yezitshalo bathole iminonjana eminingi ye-pterostilbene ezinhlotsheni zezitshalo ezingaphezu kuka-70. Abakhiqizi abajwayelekile amagilebhisi, amantongomane (njengama-alimondi), namajikijolo (njengama-blueberries nama-raspberries).
Ezinye izitshalo ezikhiqiza i-pterostilbene-secreting zifaka imivini ne-heartwood.
Yiziphi Izinzuzo Zezempilo Ze-Pterostilbene?
1. Ukulwa namaRadical Amahhala
Ama-radicals wamahhala ayimikhiqizo yezinqubo ezahlukahlukene ze-metabolic. Lezi zinhlanganisela ngokuvamile azinangozi ekugxilweni okuphansi. Kodwa-ke, uma evunyelwe ukuthi aqongelele ngaphezu kwemikhawulo ethile, ama-radicals mahhala angabangela ukucindezeleka kwe-oxidative kumaseli, amaprotheni, ne-DNA.
Ukucindezeleka okwenziwe nge-oxidative kuyingozi enkulu yezifo ezingapheli.
Ucwaningo lukhombisile ukuthi ama-stilbenoid afana ne-pterostilbene anganciphisa ingcindezi ye-oxidative ngokusebenzisa ukukhishwa kwama-radical mahhala. Lezi zinhlanganisela zinciphisa ama-radicals mahhala emzimbeni, ziwavimbele ukuthi aqongelele ngaphezu kwamazinga alawulekayo.
2. Ukunciphisa Ukuvuvukala
I-Stilbenoids isiphenduke enye yezithako eziya phambili zokuphatha ukuvuvukala, futhi i-pterostilbene iphakathi nendawo yaleyo ntshisekelo.
I-Pterostilbene ingadambisa izimo ezihlukene zokuvuvukala. Ucwaningo olusekelwe kumagundane luthole ukuthi inhlanganisela ingavimbela ukusabela kokuvuvukala okubangelwa yi-ischemia.
Indlela engcono kakhulu yokuthuthukisa izakhiwo ze-pterostilbene zokuqeda ukuvuvukala ukuwusebenzisa njengesidakamizwa esizimele noma ngokuhambisana nezidakamizwa ezihambisanayo. Ungathintana nomhlinzeki wakho wokunakekelwa kwezempilo ukuze uthole imininingwane eyengeziwe ngemithi elwa nokuvuvukala eyaziwa ukuthi isebenza ngokubambisana nama-stilbenoids.
3. Ukuvimbela Ukuguga Ngaphambi Kwesikhathi
I-Pterostilbene isebenza njengemoduli yemvelo ye-nicotinamide adenine dinucleotide (NAD) oxidase.
I-NAD iyi-coenzyme ebandakanyeka emisebenzini eminingi yomzimba, ikakhulukazi i-energy metabolism. Ukubuyisela emuva ukuguga ngaphambi kwesikhathi kungenye yeziningi zakho izinzuzo zezempilo.
INicotinamide adenine dinucleotide ilwa nokuguga ngaphambi kwesikhathi ngokubhekana nezimpawu zayo eziwumgogodla, njengemibimbi namathegi esikhumba. Imiphumela yokulinganisa ye-Pterostilbene kuma-oxidase e-NAD ichaza indima yayo ekwehliseni ijubane lenqubo yokuguga yemvelo.
4. Ukusekela Impilo Yenhliziyo
Kunobufakazi obukhulayo bokuthi ukwandisa ukusetshenziswa kwe-pterostilbene kungasiza inhliziyo nempilo yenhliziyo.
Ucwaningo olulodwa lwathola ukuthi i-pterostilbene ingakwazi vimbela ukwanda kwe-aorta yemisipha ebushelelezi kumagundane ngokuvimbela izindlela ezincike ku-Akt. Lokhu kungase kunciphise umdlavuza wemithambo yegazi, ngaleyo ndlela kuthuthukise ukusebenza kwenhliziyo yonke.
Okutholakele okufanayo kuphakamisa ukuthi ukuthathwa kwe-pterostilbene kungase kusekele impilo yenhliziyo ngokwehlisa umfutho wegazi ophakeme wamaphaphu.
5. Ukuphatha isifo sikashukela
Abantu abaphila nesifo sikashukela nabo bangazuza ngokufaka i-pterostilbene. I-compound iyasebenza ngokumelene nesifo sikashukela sohlobo 1 nohlobo 2.
Ngokusho kocwaningo, imiphumela ye-pterostilbene ye-antidiabetic ivela ekhonweni layo lokukhuphula amazinga e-glycogen kanye ne-hepatic glucokinase nemisebenzi ye-phosphofructokinase. Iphinde ivimbele ukubonakaliswa komzimba kwe-serum kanye nama-cytokines e-pancreatic pro-inflammatory.
I-Pterostilbene ingase iqhubekisele phambili ukukhuthaza ukukhiqizwa kwe-glucokinase kanye ne-glucose-6-phosphatase ngenkathi icindezela imisebenzi ye-fructose-1 kanye ne-6-bisphosphatase, iyenze isebenze ngokukhethekile ngokumelene nohlobo 2 sikashukela.
Ingabe i-Pterostilbene Ingabangela Imiphumela Ebi?
Ucwaningo olulodwa lokuqala oluphenya ukuthambekela kwe-pterostilbene emiphumeleni engemihle kwakuhilela ukuphatha inhlanganisela ezifundweni zabantu amasonto ayi-6 - 8. Abacwaningi bathola ukuthi le stilbenoid yayiphephile ukuthi isetshenziswe abantu ngemithamo efinyelela ku-250 milligrams (mg) nsuku zonke.
Kodwa-ke, lolu cwaningo aluzange luhlole imiphumela engaba khona ye-pterostilbene ye-metabolic kuphrofayili ye-lipid yezifundo. Okubaluleke nakakhulu ukuthi abasebenzisi abahlukene bangabonisa ukuzwela okuhlukile nokubekezelelana kwenhlanganisela.
Isibonelo, umsebenzisi omusha we-pterostilbene angase asabele ngokumangazayo ku-stilbenoid kunabasebenzisi abajwayele. Lokho kuyiqiniso ikakhulukazi uma into itholakala njengesithasiselo sokudla, lapho imiphumela engemihle efana nokucasuka emathunjini ingase ibe ngenxa yezinye izinhlanganisela ezisebenzayo emkhiqizweni.
Qedani
I-Pterostilbene ingenye yama-stilbenoid asebenza kahle kakhulu kwezokwelapha. Ukudla okuhlanganisiwe okuvamile kungase kwelaphe futhi kuvimbele izifo ezithile ngaphandle kokubanga imiphumela emibi kakhulu, inqobo nje uma kufakwe umthamo ophakathi.